Over 30 Years of Innovation

Since 1984, ISS has been committed to the development and design of highly sensitive scientific instrumentation for research, clinical and industrial applications. The initial product line included research-grade fluorescence instrumentation for the determination of decay times in solutions and solids; over the years a second product line for biomedical and medical applications was successfully developed.

ISS instruments are installed in universities and corporations worldwide. Our customers include several major universities, corporations, hospitals and research institutions across the globe, including, in the United States, The Mayo Foundation, the VA Administration, The National Institute of Standards and Technology, The National Institutes of Health, Oak Ridge National Laboratories and The National Aeronautics and Space Administration (NASA).


Research-Grade Fluorescence Instrumentation

ISS is dedicated to provide innovative fluorescence instrumentation to scientists working in the life sciences, drug discovery, material sciences and basic physical-chemical research applications. Our fluorescence product line includes steady-state spectrofluorometers, spectrometers for the determination of multiple decay times, time-resolved laser scanning confocal microscopes, a spectrometer for fluorescence correlation spectroscopy and a particle-tracking system for single molecule detection.

ISS has a long history of innovation and holds the relevant patents pertinent to frequency-domain instrumentation: ISS is the leader in frequency-domain time-resolved fluorescence instrumentation. ISS instruments share a series of interchangeable accessories covering a variety of applications; modular components allow the user to upgrade the instrumentation with novel capabilities as well as to assemble a custom-designed instrument. Instruments are designed with an open architecture and modular approach.

Biomedical Instrumentation

The biomedical instrumentation comprises three main platforms:

The OxiplexTS, a non-invasive tissue oximeter for the measurement of oxy- and deoxy-hemoglobin concentration in tissues, total blood volume and oxygen saturation. Its current investigation areas cover peripheral vascular disease (PVD), sleep-apnea disorders, attention deficit hyperactivity disorder (ADHD), neonatology, neurosurgery (both in operating rooms and intensive care units) and sport medicine. A clinical version of the device, the OxiplexTS200, was introduced in 2015.

MetaOx combines the NIRS technology of the OxiplexTS with Diffuse Correlation Spectroscopy (DCS) that provides the blood flow index in the tissue; the combined measurements give the oxygen consumption of the tissue or metabolism.

Imagent is an instrument for the detection of activated area of the brain under a stimulus. Light is delivered through fiber optics held in place by a headgear; fiber optics bundles collect the optical signal that traversed through the scalp and the brain areas. Up to 64 sources and 30 detectors can be arranged in various geometric patterns to capture, upon activation, both fast signals (a few milliseconds long) and slow hemodynamics changes (about 100 milliseconds and longer). The Imagent complements and replaces the functional Magnetic Resonance Imaging (fMRI) technique that is sensitive only to changes in relative deoxy-hemoglobin concentration (BOLD signal); Imagent can detect changes in both oxy- and deoxy-hemoglobin concentrations. Tests to prove the co-registration of signals acquired by Imagent with signals acquired using fMRI have been successfully completed and published.