OxiplexTSNear-infrared, non-invasive, tissue oximeter

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Overview of OxiplexTS

OxiplexTS is a revolutionary new device allowing for the absolute measurement of oxygenated and de-oxygenated hemoglobin concentrations in tissue. The device works by emitting Near Infrared (NIR) light into tissue at known distances from a collector. Low intensity light at two different wavelengths is modulated at an RF frequency of 110 MHz. The collected light is measured and processed, and the optical parameters (absorption and scattering coefficients) of the tissue (brain or muscle) are determined. Once the absorption and scattering are determined, the oxygenated and de-oxygenated hemoglobin concentrations are calculated, and, hence, the oxygen saturation.

The unique feature of the ISS OxiplexTS is the application of the theory photon migration through highly scattering that allows for the absolute measurement of the optical parameters of a highly scattering and absorption medium such as human tissue.

Since OxiplexTS measures the absorption and scattering of tissues directly, it does not require any calibration, estimation, or assumption about scattering in order to make an accurate measurement of absorption and, hence, hemoglobin concentrations. This unique ability to separate scattering from absorption sets the ISS OxiplexTS above all other NIR tissue oximeter technologies.

Notice: Investigational device. Limited by Federal (or United States) law to investigational use. The ISS OxiplexTS is presently used for research only.

Key Features of OxiplexTS

Fast Measurements Up to 50 Hz

Fast Measurements Up to 50 Hz

Absolute Measurements without Assumptions

Absolute Measurements without Assumptions

Separate Readings for Oxygenated & Deoxygenated Hemoglobin Concentrations

Separate Readings for Oxygenated & Deoxygenated Hemoglobin Concentrations

Applications of OxiplexTS

Several areas may benefit from the monitoring of the absolute values of tissue oxygenation, especially when pulse oximetry is not applicable because of the irregularity, or the lack of, the heartbeat, and in all the cases where the tissue oxygenation, and not the arterial oxygen saturation, is the parameter of interest. Therefore, the applications of the OxiplexTS include but are not limited to:

  • Peripheral Vascular Disease
  • Monitoring Brain Oxygenation in OR/ER/ICU
    • Anesthesiology
    • Cardiothoracic & Vascular Surgery
    • Neurosurgery
  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Sleep Studies
  • Women's Health and Obstetrics
  • Neonatal Applications
    • Premature Infant Intensive Care
    • Hemodynamic stress monitoring
  • Ergonomics
  • Sport Medicine and Kinesiology
    • High altitude physiology
    • Tissue Oxygenation in Hyperbaric Chambers

Product Specifications for OxiplexTS

Method of Operation
  • Frequency domain - multiple distance
Modulation Frequency
  • 110 MHz
  • Tissue oxygen saturation
  • Oxy- and deoxy-hemoglobin concentration
  • Total hemoglobin concentration
  • Absorption coefficient
  • Reduced scattering coefficient
  • Intensity and phase
Light Sources
  • 8 laser diodes emitting at 690 nm
  • 8 laser diodes emitting at 830 nm
  • Laser diodes are time multiplexed
  • Custom wavelengths available
Light Detectors
  • Photomultiplier tubes
  • Computer-controlled bias voltage (Gain)
  • Automatic safety shutdown
Average Optical Power
  • Less than 1 mW
Number of Measurement Channels
  • 2
  • All fiber optics sensors
  • Several sensor types for different applications
  • Fiber length up to 10 m
  • MRI compatible sensors available upon request
Spatial Resolution
  • 4 Emitter-Detector distances per sensor
Data Acquisition Rate
  • From 20 ms to minutes
Maximum Experiment Duration
  • Up to several days (250,000 points)
Connection to External Computer
  • USB
Operating System
  • Windows 10
Dimensions (cm)
  • 28.9 x 14.6 x 36.2
Weight (kg)
  • 5.4
Power Requirements
  • 110 - 240 V; 50/60 Hz
Sampling Rate
  • Up to 50 Hz
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