MetaOxOxygen metabolism monitor

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Overview of MetaOx

A unique oxygen consumption monitoring technology instrument, MetaOx is capable of acquiring quantitative measurements of hemoglobin concentration and oxygenation using FDNIRS (Frequency-Domain Near Infrared Spectroscopy) and an index of blood flow using DCS (Diffusive Correlation Spectroscopy). With these parameters and the knowledge of arterial oxygen saturation (from a pulse oximeter), the instrument determines the cerebral oxygen metabolism (CMRO2) index.

Development of the MetaOx technology was funded by an SBIR grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development at NIH and the instrument was developed in collaboration with Prof. Maria Angela Franceschini of the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital and Prof. Arjun Yodh of the University of Pennsylvania.

Notice: Investigational device. Limited by Federal (or United States) law to investigational use. The ISS MetaOx is presently used for research only.

Key Features of MetaOx

Monitors Changes in Metabolic Rate

Monitors Changes in Metabolic Rate

Fast Measurements Up to 50 Hz

Fast Measurements Up to 50 Hz

Simultaneous Measurements in FDNIRS and DCS

Simultaneous Measurements (FDNIRS & DCS)

How MetaOx Works

MetaOx combines three technologies respectively:

From these measurements the MetaOx determines the cerebral metabolic rate of oxygen extraction, CMRO2.

  • FDNIRS, the quantitative frequency-domain near-infrared, capable of providing absolute values of oxy- and deoxy-hemoglobin concentration in tissues
  • Pulse oximetry for the measurement of arterial oxygen saturation
  • DCS, Diffusive Correlation Spectroscopy, for the measurement of blood flow

Applications of MetaOx

In infants:

  • Assess microvascular cerebral blood flow (CBF)
  • Development of cerebral metabolic rate of oxygen extraction (CMRO2)
  • Blood flow and CMRO2 functional changes

In infants and children after cardiac surgery (when born with heart defects):

  • Assess pre-operative hemodynamics
  • Monitoring early postoperative changes
  • Monitoring the cerebral oxygen metabolism
  • Assess cerebrovascular reactivity
  • Response to sodium bicarbonate treatment

In adults:

  • Measure the impairment of cerebrovascular reactivity in ischemic stroke patients
  • Estimate autoregulation and CBF responses in patients with traumatic brain injury and subarachnoid hemorrhage
  • Assess cerebrovascular reactivity in response to pharmacologically induced vasodilation in healthy adults and in patients suffering from carotid artery stenosis and/or occlusion
  • Risk assessment in patients with steno-occlusive lesions of the internal carotid artery
  • Monitor adult patients undergoing carotid endarterectomy
  • Assess hemodynamic responses of adults to low-frequency repetitive TMS applications
  • Study CBF response variations with age

Product Specifications for MetaOx

Lasers
  • NIRS: 660, 690, 705, 730, 760, 785, 810, 830 nm; 5 - 9 mW
  • DCS: 850 nm, long coherence length; 50 mW
Detectors
  • NIRS: Qty. 4 PMTs, GaAs; computer-controlled gain
  • DCS: Qty. 8 APDs; photon counting mode
Acquisition electronics
  • NIRS: 4-channel A/D converter
  • DCS: 4-channel, 8-channel digital correlator
Sensors
  • All Fiber Optic
Computer and Operating System:
  • Touch-screen monitor, Windows 8, 64-bit
Power Requirements:
  • Universal power input: 110 - 240 V, 250 W
Dimensions (cm)
  • 45 x 24 x 44
Weight
  • 19 kg
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